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Herpes Simplex Virus Type 2 Antibody, IgG (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies in your blood that your immune system produces in response to the herpes simplex virus type 2 (HSV-2), which causes genital herpes.

Quick summary

["It helps determine if you’ve been exposed to HSV-2 or if you have an active infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48401-4
Short code
HSV2 gG IgG CSF-aCnc
Synonyms
HSV2 gG IgG CSF-aCnc
Category
glucose
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for IgG antibodies, which are part of your immune system’s defense against HSV-2. These antibodies develop after an initial infection and can remain in your blood for years. The presence of these antibodies suggests past exposure, but they don’t always indicate an active infection at the time of testing.

Why It’s Done

Doctors may order this test if you have symptoms like sores, pain, or unusual discharge in the genital or anal area, or if you’ve had multiple sexual partners. It can also be used for screening in certain high-risk groups or as part of preconception counseling.

When Results May Be Positive

A positive result means you likely have had HSV-2 at some point, but it doesn’t confirm an active infection. Active herpes sores require a separate viral culture or PCR test. If you’re pregnant, this test helps assess risk to your baby.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm in a clinic or lab. The process takes a few minutes, and you may feel slight discomfort.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Antibody to HSV-2

Frequently asked questions

Can this test tell me if I have an active herpes infection right now?
No, this IgG antibody test only shows if you’ve ever been exposed to HSV-2. To check for an active infection, you’d need a separate test like a viral culture or PCR test, which looks for the virus itself in your body fluids.
How long does it take to get results from this test?
Results are typically available within 1–3 business days, depending on your lab’s processing schedule. Your healthcare provider will contact you once they have the results.
What if my test is positive for HSV-2 antibodies?
A positive result means you’ve likely had HSV-2 at some point, but it doesn’t mean you’re currently contagious. If you’re concerned about transmission or need treatment, discuss this with your doctor. They may recommend additional testing or counseling based on your symptoms and medical history.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy