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Herpes Simplex Virus Type 2 Immunoglobulin G (IgG) Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies to herpes simplex virus type 2 (HSV-2) in your blood. These antibodies indicate past or current infection with HSV-2, which can cause genital herpes.

Quick summary

["This test helps determine if you’ve ever been exposed to HSV-2, even if you don’t currently have symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5209-2
Short code
HSV2 IgG Ser IA-aCnc
Synonyms
HSV2 IgG Ser IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies specific to HSV-2. IgG antibodies develop after an initial infection and can remain in your system for years. This test is not used to diagnose an active outbreak but can confirm past exposure.

Why Might You Need This Test?

Your healthcare provider may recommend this test if you have a history of genital herpes, have symptoms suggestive of HSV-2 infection, or are at higher risk due to sexual history or exposure.

What to Expect During the Test

A blood sample will be taken from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The sample is then sent to a lab for antibody testing.

What Are the Possible Results?

A positive result means you likely had HSV-2 at some point in the past. A negative result suggests you either have never been infected or the infection has cleared. Results alone don’t indicate whether you currently have an active infection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-2 IgG Antibody

Frequently asked questions

Why is this test important?
This test helps confirm a history of HSV-2 infection, which is crucial for managing long-term health, especially if you have a history of recurrent outbreaks or complications. It can also guide counseling about sexual health and transmission risks.
How does this test differ from an HSV-2 PCR test?
Unlike a PCR test, which detects the virus itself during an active outbreak, this test looks for antibodies. It can show past infection but won’t confirm an active infection.
What if I have a positive result?
A positive result means you’ve had HSV-2, but it doesn’t change your current health status. You may still receive treatment for active symptoms if needed. Your healthcare provider can discuss next steps, including managing outbreaks and preventing transmission.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy