Herpes Simplex Virus 2 Immunoglobulin G Antibody (Serum/Plasma)
This test measures the presence of antibodies to the herpes simplex virus type 2 (HSV-2), which causes genital herpes. Antibodies indicate past or current infection.
["This test helps determine if you’ve ever been exposed to genital herpes."]
Key facts at a glance
- LOINC
- 43180-9
- Short code
- HSV2 IgG SerPl Ql IA
- Synonyms
- HSV2 IgG SerPl Ql IA
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted infection (STI) that can cause painful sores or blisters, especially in the genital area. While some people may not experience symptoms, others may develop them shortly after infection. This test helps healthcare providers assess your risk for HSV-2 and guide treatment or prevention strategies, such as antiviral medications or condoms.
What the Test Measures
The test detects **IgG antibodies** to HSV-2 in your blood. These antibodies develop after an initial infection and can remain in your system for years, even if the virus is inactive. Unlike HSV-1 (which often causes cold sores), HSV-2 is strongly linked to genital herpes.
When You Might Need This Test
You may need this test if you have symptoms of genital herpes (e.g., sores, itching, or pain in the genital or anal area), if you’ve had multiple sexual partners, or if you’re being evaluated for an STI. It can also be used during pregnancy to assess risk of transmission to your baby.
What to Expect During Testing
A small blood sample is drawn from a vein in your arm. The sample is sent to a lab for testing. Results are typically available within a few days. If you’re pregnant, your provider may recommend this test during your prenatal care.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive results indicate past or current HSV-2 infection. While antibodies don’t always mean active disease, they confirm exposure. If you test positive, your provider may recommend antiviral treatment to manage symptoms, reduce transmission risk, and prevent complications (e.g., recurrent outbreaks or complications during pregnancy). Negative results mean you likely haven’t been infected with HSV-2, but they don’t rule out other STIs.
Short name
HSV-2 IgG Antibody
Frequently asked questions
How long do HSV-2 antibodies stay in the blood?
Can I get HSV-2 if I’ve never had symptoms?
What if my test is positive but I’ve never had symptoms?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy