Herpes Simplex Virus Type 2 Immunoglobulin G (IgG) Antibody, Serum

What Does This Test Measure?

The test detects **IgG antibodies**—a type of protein your immune system produces in response to past exposure to HSV-2. Unlike IgM antibodies, which appear shortly after infection, IgG antibodies remain in your system for longer, indicating past infection rather than an active outbreak.

Why Might You Need This Test?

Your healthcare provider may recommend this test if you have symptoms of genital herpes (e.g., sores, itching, or pain in the genital or anal area), a history of HSV-2 infection, or if you’re at risk due to sexual history. It can also help confirm a diagnosis when other tests are inconclusive.

How Is the Test Performed?

A small blood sample is drawn from a vein in your arm. The sample is sent to a lab where it’s tested for HSV-2 IgG antibodies using an **immunoassay** method, which detects the presence of these antibodies without measuring virus activity.

What Are the Possible Results?

A positive result means you likely have **past exposure** to HSV-2, but it does not confirm an active infection. A negative result suggests you have not been exposed to HSV-2 in the past or currently. Results are qualitative (positive/negative) and do not provide a timeline of infection.