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Herpes Simplex Virus 2 Immunoglobulin G (IgG) Antibody, Qualitative or Semi-Quantitative Measurement by Serological Test (CSF)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the herpes simplex virus type 2 (HSV-2) in your cerebrospinal fluid (CSF). Antibodies are proteins your immune system makes to fight infections.

Quick summary

["Helps diagnose or monitor HSV-2 infection in the central nervous system, such as meningitis or encephalitis caused by HSV-2."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110917-2
Short code
HSV2 IgM Msmt CSF
Synonyms
HSV2 IgM Msmt CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like severe headache, neck stiffness, confusion, fever, or neurological issues that could suggest a serious infection involving the brain or spinal cord. They may also order it if you have a history of HSV-2 infection or if you’re at risk for complications from the virus.

What to Expect Before the Test

No special preparation is needed for this test. A healthcare professional will collect a small amount of cerebrospinal fluid through a procedure called a lumbar puncture (spinal tap). This involves inserting a needle into your lower back to draw fluid from your spinal canal.

What to Expect During the Test

The procedure is usually done in a hospital or clinic setting. You may feel pressure or a slight ache where the needle is inserted, but it’s generally well-tolerated. You’ll lie on your side with your knees bent, and the area will be numbed with a local anesthetic.

What to Expect After the Test

After the procedure, you’ll rest for a short time to ensure there are no complications. You may experience mild soreness or a small bruise at the injection site. Stay hydrated and avoid strenuous activity for a few hours. You’ll need someone to drive you home if you’re feeling dizzy or lightheaded.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-2 IgG Antibody (CSF)

Frequently asked questions

What Does a Positive Result Mean?
A positive result suggests that your immune system has recognized HSV-2 in your spinal fluid, which could indicate an active infection or past exposure. This may help confirm a diagnosis of HSV-2-related neurological issues like meningitis or encephalitis.
What Does a Negative Result Mean?
A negative result means no detectable HSV-2 antibodies were found in your CSF at the time of testing. This could mean the infection isn’t present or is too early to detect. Your provider may recommend follow-up testing or additional evaluation based on your symptoms and medical history.
How Often Should This Test Be Repeated?
The frequency of retesting depends on your symptoms, medical history, and provider’s recommendations. If you have an ongoing neurological concern or suspected HSV-2 infection, your provider may order this test again if needed, possibly every few weeks or months to monitor progression or response to treatment.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy