Herpes Simplex Virus Type 2 Immunoglobulin M Antibody (Serum) – Qualitative or Semi-Quantitative
This test detects antibodies to herpes simplex virus type 2 (HSV-2), which can help identify past or recent infection with HSV-2, the virus responsible for genital herpes.
["This test may help confirm if you’ve been exposed to HSV-2 or if symptoms suggest an active infection."]
Key facts at a glance
- LOINC
- 111332-3
- Short code
- HSV2 IgM Msmt Ser
- Synonyms
- HSV2 IgM Msmt Ser
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test measures **IgM antibodies** produced by your immune system in response to HSV-2 infection. IgM antibodies typically appear shortly after exposure and can indicate an acute (recent) infection. This test is qualitative or semi-quantitative, meaning it either confirms the presence of antibodies or provides a relative measure of their level.
Why It’s Done
Your healthcare provider may order this test if you have symptoms like sores, itching, or unusual discharge in the genital or anal area, or if you’ve been diagnosed with genital herpes and want to check for new infections. It can also be used during pregnancy to assess risk of transmission to the baby.
How the Test Works
A blood sample is taken from a vein in your arm. The serum (liquid part of blood) is then tested for HSV-2 IgM antibodies using an immunoassay method, which detects the presence of these antibodies with high sensitivity.
What to Expect Before the Test
No special preparation is needed, but inform your provider if you’re taking medications that might affect blood tests or if you have a bleeding disorder. Avoid alcohol for 24 hours before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive results suggest recent HSV-2 infection, which may require treatment to manage symptoms and reduce transmission. However, IgM antibodies can sometimes persist for months or years after infection. A positive result does not always mean you have an active outbreak; some people may not have symptoms. Always consult your healthcare provider for interpretation, as other factors (like prior infections) can influence results.
Short name
HSV-2 IgM Antibody Test
Frequently asked questions
How long does it take to get results?
Can I have false-positive or false-negative results?
Does this test tell me if I have an active outbreak?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy