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Herpes Simplex Virus Type 2 Immunoglobulin G (IgG) Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies against herpes simplex virus type 2 (HSV-2) in your blood. Antibodies are proteins your immune system makes to help fight infections.

Quick summary

["This test helps determine if you’ve ever been exposed to HSV-2, which can cause genital herpes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5210-0
Short code
HSV2 IgM Ser IA-aCnc
Synonyms
HSV2 IgM Ser IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like sores or itching around your genitals, anus, or mouth. It can also be used to check for past exposure, especially if you have a history of genital herpes or are at higher risk for infection.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. It usually takes a few minutes, and you may feel a brief pinch. The blood sample is then sent to a lab for testing.

What the Test Results Mean

If your test shows a positive result for HSV-2 IgG antibodies, it means your immune system has recognized and fought off HSV-2 in the past. This does not indicate whether you currently have an active infection but confirms past exposure. A negative result means you likely haven’t been exposed to HSV-2 or have very low levels of antibodies.

Possible Side Effects

Most people experience only minor side effects, such as a small bruise, slight pain, or swelling at the injection site. Rarely, you might have a mild fever or feel tired afterward.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is important for diagnosing past exposure to HSV-2, which can help guide treatment decisions, especially if you have recurrent outbreaks or are at risk for complications. It can also be used in screening for sexually transmitted infections (STIs) and in counseling about infection risks and prevention strategies.

Short name

HSV-2 IgG Antibody

Frequently asked questions

What does a positive result mean?
A positive result means your body has produced antibodies against HSV-2, indicating you’ve likely had the virus at some point in the past. This does not mean you currently have an active infection, but it confirms you’ve been exposed to the virus.
Can this test detect an active infection?
No, this test specifically measures IgG antibodies, which develop after an initial infection and remain in your system for years. To detect an active infection, your provider may use a different test, such as a viral culture or PCR test.
How often should I get this test?
You typically don’t need to get this test regularly unless you have symptoms of HSV-2, a history of genital herpes, or are at higher risk for infection (e.g., due to sexual history or immune conditions). Always follow your healthcare provider’s recommendations.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy