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Herpes Simplex Virus 2 Immunoglobulin G Antibody (IgG) – Serology

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the herpes simplex virus type 2 (HSV-2), which can help identify past or current infection with this virus. Antibodies are the body’s immune response to infection and may remain in the blood for years after recovery.

Quick summary

["This test helps determine if you’ve ever been exposed to HSV-2, a virus that can cause genital herpes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
32688-4
Short code
HSV2 IgM Ser Ql
Synonyms
HSV2 IgM Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like sores, itching, or unusual discharge in the genital area, or if you’ve had multiple sexual partners. It may also be used during pregnancy to assess risk of transmission to the baby or in cases of recurrent outbreaks.

What to Expect During the Test

A small amount of blood is drawn from a vein in your arm. You may feel a slight pinch, but it usually takes only a few minutes. The blood is then sent to a lab for testing.

Understanding Your Results

Positive results indicate the presence of HSV-2 antibodies, suggesting past infection. Negative results mean no detectable antibodies, but this doesn’t rule out current infection—other tests may be needed. Always discuss results with your provider.

What This Test Can’t Tell You

This test cannot confirm an active infection at the time of testing. It also doesn’t distinguish between HSV-1 and HSV-2, though HSV-1 is more commonly associated with oral herpes.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-2 IgG Antibody

Frequently asked questions

How often should I get this test?
This test is typically done once if you’re at risk or have symptoms. If you have recurrent outbreaks or ongoing concerns, your provider may recommend retesting or additional evaluation.
Can I still have sex if I have HSV-2?
Yes, but it’s important to use barrier protection (like condoms) to reduce the risk of spreading the virus. HSV-2 can be transmitted even when symptoms aren’t visible.
What does a high or low antibody level mean?
A high antibody level means you’ve likely had HSV-2 before, but it doesn’t indicate how long ago or if you’re currently infected. A low or negative level suggests no detectable antibodies, which may mean you’ve never been exposed or the test was taken too soon after infection.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy