Herpes Simplex Virus Type 2 Immunoglobulin G Antibody (IgG) – Serology

What This Test Measures

The test looks for IgG antibodies specific to HSV-2. These antibodies develop after your body has been exposed to the virus, whether through infection or vaccination. IgG antibodies are typically present for long-term immunity but may decline over time if the virus remains active.

Why It’s Ordered

Your healthcare provider may order this test if you have symptoms like sores, pain, or unusual discharge in the genital or anal area, or if you’ve had multiple sexual partners. It can also be used to confirm a diagnosis in people with suspected genital herpes or to monitor recurrent infections.

Sample Collection and Process

A blood sample is drawn from a vein in your arm. The serum (liquid part of blood) is then tested using an immunoassay method to detect HSV-2-specific IgG antibodies. Results are reported as positive or negative, or sometimes with a quantitative measure of antibody levels.

Interpreting Your Results

A positive result indicates the presence of HSV-2-specific IgG antibodies, suggesting past infection. However, it does not distinguish between active infection and past exposure. A negative result means no detectable antibodies were found at the time of testing.