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Herpes Simplex Virus Type 2 Immunoglobulin G (IgG) Antibody, Quantitative

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies in your blood that your immune system produces in response to the herpes simplex virus type 2 (HSV-2), which causes genital herpes.

Quick summary

["This test helps determine if you’ve been exposed to HSV-2 and whether your body has developed immunity over time."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
45210-2
Short code
HSV2 IgM Ser Ql IF
Synonyms
HSV2 IgM Ser Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of genital herpes, such as sores or itching in the genital area, or if you have a history of recurrent outbreaks. It can also be used to assess exposure in individuals without current symptoms, such as during pregnancy or for diagnostic confirmation in suspected cases.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm, similar to other blood tests. If you’re pregnant or have concerns about blood draws, discuss these with your provider beforehand.

What the Test Results Mean

Positive results indicate the presence of HSV-2 antibodies, suggesting past or current infection. Negative results mean no detectable antibodies, which may mean you’ve never been exposed or the test was taken too early after exposure. Results alone don’t confirm active infection; they only indicate exposure history.

How Results Are Used

These results help guide treatment decisions, monitor immunity, and assess risk for transmission—especially important during pregnancy or in sexual health evaluations. They don’t replace clinical evaluation of symptoms or active infection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Antibody to HSV-2

Frequently asked questions

What does a positive result mean for my health?
A positive result means your immune system has detected past exposure to HSV-2, but it doesn’t indicate whether you currently have an active infection. If you have symptoms like sores or itching, you should discuss them with your provider, as active infection may require treatment.
Can this test be used to confirm an active herpes outbreak?
No, this test only measures antibodies from past exposure. To confirm an active herpes outbreak, your provider may order additional tests, such as viral culture or PCR testing, which look for the virus itself in your body fluids.
How soon after exposure can I expect accurate results?
Results may take weeks to develop after exposure because antibodies take time to build up. If you suspect recent exposure, your provider may recommend additional testing or follow-up to assess active infection.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy