Herpes Simplex Virus 2 Immunoglobulin G (IgG) Antibody, Serologic Test (Titration)

What Does This Test Measure?

The test detects antibodies (IgG) produced by your immune system in response to HSV-2. These antibodies indicate that your body has encountered the virus at some point, even if you no longer have symptoms. Unlike active infection tests, this does not show whether you have an ongoing viral load.

Why Might You Need This Test?

Doctors may order this test if you have a history of genital herpes, unexplained genital sores, or if you’re at risk for sexually transmitted infections. It can also be used for screening in certain populations or to evaluate immune response after treatment.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is sent to a lab where it is analyzed using an immunoassay method to detect HSV-2 IgG antibodies. Results are typically reported as positive or negative, or sometimes as a quantitative value indicating antibody level.

What Are the Results Typically Used For?

Positive results suggest past exposure to HSV-2, meaning you’ve likely been infected with the virus at some point. Negative results mean the test did not detect antibodies, which could indicate you’ve never been exposed or the test was taken too early after exposure. This test alone does not diagnose an active infection.