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Herpes Simplex Virus Type 2 Immunoglobulin G (IgG) Antibody, Titration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies against herpes simplex virus type 2 (HSV-2) in your blood. Antibodies are proteins your immune system produces to help fight infections.

Quick summary

["This test helps determine if you’ve ever been exposed to HSV-2, which can cause genital herpes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26927-4
Short code
HSV2 IgM Titr Ser IF
Synonyms
HSV2 IgM Titr Ser IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies specific to HSV-2. IgG antibodies are typically present in the blood if you’ve been infected with HSV-2 at some point, even if you don’t currently have symptoms. This type of antibody provides long-term immunity and is not affected by recent infections.

Why Might You Need This Test?

Your healthcare provider may recommend this test if you have symptoms like sores, pain, or unusual discharge in the genital or anal area, or if you have a history of genital herpes. It can also be used during pregnancy to check for HSV-2 infection to prevent transmission to your baby.

What Does a Positive Result Mean?

A positive result means your blood contains antibodies against HSV-2, indicating past exposure to the virus. However, it does not confirm whether you currently have an active infection. If you have symptoms, additional testing may be needed to check for active herpes.

What Does a Negative Result Mean?

A negative result means your blood does not currently show detectable antibodies against HSV-2. This could mean you have never been exposed to the virus, but it’s also possible you were exposed recently and haven’t developed enough antibodies yet.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-2 IgG Antibody Test

Frequently asked questions

How is this test performed?
This test involves drawing blood from a vein in your arm. The blood sample is then sent to a lab for analysis using an immunoassay method to detect HSV-2 antibodies.
What are the possible side effects of blood drawing?
The most common side effect of blood drawing is a small bruise, redness, or slight pain at the injection site. Rarely, you might feel lightheaded or dizzy for a short time, especially if you stand up too quickly.
How long does it take to get the results?
Results are typically available within 2 to 5 business days, depending on your healthcare provider’s lab processing times.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy