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Herpes Simplex Virus Type 2 IgG Antibody, Serum (Qualitative Immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the herpes simplex virus type 2 (HSV-2), which causes genital herpes. Antibodies indicate past or current infection.

Quick summary

["This test helps determine if you’ve been exposed to HSV-2, even if you don’t have symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14085-5
Short code
HSV2 Islt Ql IF
Synonyms
HSV2 Islt Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies specific to HSV-2. These antibodies develop after infection and can persist for years. A positive result suggests past or ongoing infection, but it does not confirm active symptoms.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms of genital herpes (e.g., sores, itching) or if you’re at higher risk for infection (e.g., sexually active without protection, history of STIs). It can also be used for screening or monitoring in certain clinical settings.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample from a vein in your arm. The test is typically done in a lab setting and results are usually available within a few days.

What the Results Mean

A positive result means you likely have antibodies to HSV-2, indicating past infection. A negative result means no detectable antibodies were found at this time. Results alone don’t confirm active disease—symptoms or other tests may be needed for diagnosis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Understanding Your Results

Short name

HSV-2 IgG Antibody (Serum)

Frequently asked questions

How long do HSV-2 IgG antibodies last?
IgG antibodies to HSV-2 can remain in your system for years after infection, sometimes even decades. However, they don’t guarantee immunity against reinfection. If you’re sexually active, ongoing protection against STIs is still important.
Can this test be used to diagnose active herpes?
No, this test alone cannot diagnose active herpes. It only shows if you’ve been exposed to HSV-2. For active infection, your provider may use other tests or clinical evaluation.
What if I have a positive result but no symptoms?
A positive result means you’ve likely had HSV-2 at some point. You may not have symptoms, but you can still transmit the virus to others during outbreaks or even when asymptomatic. Discuss your results with your healthcare provider for guidance on managing your health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy