Herpes Simplex Virus Antibody, Serum (Qualitative or Quantitative)

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like sores, pain, or unusual discharge in the mouth, genital area, or anus. It may also be used to confirm a diagnosis in people with no obvious symptoms or to check for recurrence of infection.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. If you’re pregnant or have a history of bleeding disorders, let your provider know before the test.

What the Test Results Mean

Positive results indicate the presence of HSV antibodies, suggesting past infection. Negative results mean no detectable antibodies, but this doesn’t always rule out current infection—other tests may be needed. False negatives can occur if tested too soon after exposure.

Common Reasons for Testing

This test is often used to diagnose herpes infections, especially in cases where symptoms are unclear or to monitor treatment effectiveness. It can also help determine if you’ve been exposed to HSV if you’re pregnant or planning pregnancy.