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Herpes Simplex Virus Antibody, Serum (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to herpes simplex virus (HSV), a common virus that can cause cold sores or genital infections. Antibodies indicate your immune system has recognized the virus, often from past infection.

Quick summary

["This screening helps determine if you’ve been exposed to HSV or if you may have an active infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22339-6
Short code
HSV Ab Ser Ql
Synonyms
HSV Ab Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific proteins (antibodies) your body produces in response to HSV. These antibodies are part of your immune system’s way of fighting the virus. A positive result suggests past exposure or possible infection, but it doesn’t confirm an active outbreak.

Why You Might Need This Test

Doctors may order this test if you have symptoms like sores, fever, or unusual rashes that could be linked to HSV. It’s also used in pregnancy to check for HSV antibodies to prevent transmission to your baby.

What to Expect Before the Test

No special preparation is needed. A blood sample is taken from a vein in your arm. You may feel a slight pinch, but it’s usually over quickly. If you’re pregnant, let your healthcare provider know before the test.

What to Expect During the Test

The blood sample is sent to a lab for testing. Results are typically ready within a few days. A positive result means antibodies are present, but further testing may be needed to confirm active infection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV Antibody Screen

Frequently asked questions

How long does it take to get results?
Results are usually available within 2 to 5 business days, depending on your lab’s processing time. Your healthcare provider will contact you with the results.
Can I have a follow-up test if my results are positive?
Yes, if your test is positive, your doctor may recommend additional testing, such as viral culture or PCR, to check for an active HSV infection. These tests can confirm whether you’re currently infected or if the antibodies are from past exposure.
What does a negative result mean?
A negative result means your blood sample did not detect HSV antibodies at the time of testing. This could mean you’ve never been exposed to HSV or that the test was taken too early after exposure. Follow-up testing may be needed if you suspect you’ve been exposed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy