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Human Herpesvirus 6 (HHV-6) IgG Antibody, Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against Human Herpesvirus 6 (HHV-6), a virus that can cause infections and sometimes fever, rash, or other symptoms. Antibodies indicate past exposure or immunity to the virus.

Quick summary

["This test helps determine if you’ve been exposed to HHV-6 or if your immune system has developed immunity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44516-3
Short code
HSV Ag Cvx Ql IF
Synonyms
HSV Ag Cvx Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects **IgG antibodies**—a type of immune protein your body produces in response to past exposure to HHV-6. IgG antibodies suggest long-term immunity or prior infection, but they don’t confirm an active infection. This test is typically used in research or specialized clinical settings.

Why Might You Need This Test?

Doctors may order this test if you have symptoms like severe or persistent fever, neurological issues, or if you’re being evaluated for complications related to HHV-6, such as in certain immune disorders or transplant patients. It’s not routinely part of standard health screenings.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample (serum or plasma) during a routine lab visit. If you’re on blood-thinning medications, let your provider know before the test.

What Are the Possible Results?

Results are qualitative (positive/negative) and indicate whether antibodies were detected. A positive result suggests past exposure or immunity, but it doesn’t confirm active infection. Follow-up testing may be needed if symptoms persist.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Understanding Your Results

Short name

HHV-6 IgG Antibody

Frequently asked questions

Why do I need this test?
This test is primarily used in research or specialized clinical contexts to assess exposure to HHV-6. It’s not a standard screening tool for general health. If you’re being evaluated for a suspected HHV-6-related condition, your doctor will discuss the need for this test.
What does a positive result mean?
A positive result means your body has produced antibodies against HHV-6, indicating past exposure or immunity. However, it does not confirm an active infection. If you’re experiencing symptoms, further testing may be required to determine if you have an active HHV-6 infection.
Can this test be used to diagnose an active HHV-6 infection?
No, this test alone cannot diagnose an active HHV-6 infection. It only measures antibodies, which indicate past exposure. For diagnosing an active infection, other tests or clinical correlation may be needed, such as viral load testing or symptom evaluation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy