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Human Herpesvirus 8 (HHV-8) Antibody, Serum (Qualitative Immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of antibodies to Human Herpesvirus 8 (also called Kaposi’s sarcoma-associated herpesvirus), a virus linked to certain cancers and infections.

Quick summary

["Helps determine if your immune system has encountered HHV-8, which may be important for monitoring or diagnosing related health conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5853-7
Short code
HSV Ag Skin Ql IF
Synonyms
HSV Ag Skin Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects antibodies produced by your immune system in response to exposure to HHV-8. Antibodies are proteins that help identify and fight foreign substances, like viruses. This test is qualitative, meaning it only tells whether antibodies are present or not, rather than measuring their exact amount.

Why It Might Be Ordered

Doctors may order this test if you have symptoms or conditions associated with HHV-8, such as Kaposi’s sarcoma (a type of cancer), certain lymphomas, or persistent infections. It can also be part of monitoring for people at higher risk, like those with weakened immune systems or specific medical conditions.

Sample Collection and Preparation

A blood sample is taken from a vein in your arm. The blood is processed to separate the serum (the liquid part without blood cells), which is then tested for HHV-8 antibodies using an immunoassay method. This process helps ensure accurate detection of the antibodies.

What to Expect Before the Test

There are no special preparations needed for this test. You may have some mild discomfort from the needle, but it usually goes away quickly. If you are on blood-thinning medication or have a history of bleeding problems, let your healthcare provider know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HHV-8 Antibody Screen

Frequently asked questions

How long does it take to get the results?
Results are typically available within a few days to a week after the sample is collected, depending on the lab’s processing schedule. Your healthcare provider will contact you with the results once they are ready.
Can I have false positive or false negative results?
Like any test, there is a small chance of false results. False positives might occur if you have been exposed to other similar substances or if there are other medical conditions affecting your immune response. False negatives are less common but can happen if the virus is actively replicating at the time of testing or if the antibody levels are very low.
What does a positive result mean for my health?
A positive result means your immune system has detected HHV-8 antibodies, which could indicate past exposure. However, it does not confirm current infection or disease. Your healthcare provider will discuss the results in the context of your medical history and symptoms to determine the next steps, which may include further testing or monitoring.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy