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Herpes Simplex Virus Antibody Screening (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to herpes simplex virus (HSV), which can help determine if you’ve ever been exposed to the virus or if you have an active infection.

Quick summary

["This screening helps guide whether further testing or treatment is needed for HSV exposure or infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5855-2
Short code
HSV Ag Spec Ql IF
Synonyms
HSV Ag Spec Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects antibodies produced by your immune system in response to HSV exposure. Antibodies are proteins that recognize and fight foreign substances, like viruses. This test does not directly measure the virus itself but indicates past or current immune response.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms like sores, fever, or other signs of HSV infection, or if you’ve had close contact with someone known to have HSV. It can also be used to screen for past exposure, especially in high-risk groups.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The blood is processed to separate serum or plasma, which is then tested for HSV antibodies. This process is quick and typically done in a lab setting.

What to Expect Before the Test

No special preparation is needed. You may want to avoid alcohol for 24 hours before the test, as it can affect blood test results. Wear comfortable clothing and bring any necessary medical devices or medications with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV Antibody Screen

Frequently asked questions

How long does it take to get the results?
Test results are usually available within 1 to 3 business days, depending on your lab’s processing time.
What does a positive result mean?
A positive result means your body has produced antibodies against HSV, which could indicate past exposure. It does not confirm an active infection without additional testing.
Can I get HSV from a positive antibody test?
No, a positive antibody test does not mean you currently have an active HSV infection. It only shows your immune system has encountered the virus before. If you suspect an active infection, consult your healthcare provider for further evaluation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy