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Herpes Simplex Virus Antibody (IgG) – Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against herpes simplex virus (HSV), a common virus that can cause cold sores or genital infections. Antibodies indicate past or current infection.

Quick summary

["This test helps determine if you’ve been exposed to HSV or if your immune system is responding to it."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44510-6
Short code
HSV Ag Vag Ql
Synonyms
HSV Ag Vag Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects IgG antibodies specific to HSV, which your immune system produces in response to infection. IgG antibodies remain in your blood for years after initial exposure, helping your body fight future infections.

Why It’s Done

Doctors may order this test if you have symptoms like sores, pain, or recurrent infections (e.g., cold sores, genital ulcers) that suggest HSV. It’s also used to confirm past infection or assess immune response in certain conditions.

What to Expect Before the Test

No special preparation is needed. A blood sample is drawn from a vein, usually in your arm. The process takes a few minutes, and you may feel slight discomfort.

What the Results Mean

Positive results indicate the presence of IgG antibodies, suggesting past HSV exposure. Negative results mean no detectable antibodies at this time, but HSV could still be active without antibody presence.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

IgG HSV Antibody

Frequently asked questions

Is HSV contagious?
Yes, HSV is highly contagious through skin-to-skin contact, saliva, or during active outbreaks. Avoiding close contact with sores and practicing safe sex can reduce risk.
Can this test predict future outbreaks?
No, this test only shows past exposure. HSV can reactivate even if antibodies are present, so symptoms and lifestyle factors (stress, illness) play a role in outbreaks.
What if my test is positive but I don’t have symptoms?
A positive result means you’ve likely been exposed to HSV at some point. You may still carry the virus without symptoms, but it doesn’t mean you can’t pass it to others during outbreaks.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy