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Herpes Simplex Virus (HSV) Culture (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of **Herpes Simplex Virus (HSV)** in your blood using a culture method. It helps determine if you have an active HSV infection, which can be important for managing symptoms and preventing spread.

Quick summary

["A culture test helps identify active HSV infection in your bloodstream, guiding treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35420-9
Short code
HSV Cvx Cult
Synonyms
HSV Cvx Cult
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
organism-specific-culture
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test involves growing HSV from a sample of your blood (either serum or plasma) in a lab setting. If HSV is present, it will grow and be identified under a microscope or through other lab techniques. This is different from antibody tests, which detect past exposure rather than active infection.

Why It’s Done

Your healthcare provider may order this test if you have symptoms like sores, fever, or neurological issues that could suggest an active HSV infection. It’s also used to confirm infections in people with weakened immune systems or those at high risk of complications.

Sample Collection and Process

A blood sample is taken from a vein, usually in your arm. The sample is then processed to separate serum or plasma, which is sent to the lab for culture. Results may take several days to weeks, as HSV growth requires time to develop.

What the Results Mean

If HSV is detected in your blood culture, it confirms an active infection. If no growth is seen, it means HSV was not present in the sample at the time of testing. Results should always be interpreted by your healthcare provider in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV Culture (Serum/Plasma)

Frequently asked questions

How often do I need this test?
This test is typically done only when you have symptoms of an active HSV infection or if your doctor suspects a reactivation of the virus. Follow-up testing may be needed if symptoms persist or recur.
What are the possible side effects of this test?
The most common side effect is mild bruising, redness, or soreness at the needle insertion site. Rarely, there may be a reaction to the blood draw, such as swelling or pain. Most side effects are mild and resolve quickly.
Can I stop taking antiviral medication before this test?
If you’re taking antiviral medication for HSV, your doctor may advise stopping it temporarily before the test to ensure accurate results. Always follow your healthcare provider’s instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy