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Herpes Simplex Virus (HSV) DNA in Serum/Plasma by Nucleic Acid Probe

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of genetic material from the herpes simplex virus (HSV) in your blood. It helps identify active infection or viral load.

Quick summary

["Assists in diagnosing active herpes infections or monitoring viral activity in the bloodstream."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44518-9
Short code
HSV DNA SerPl Ql NAA+probe
Synonyms
HSV DNA SerPl Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like fever, sore throat, or unusual rashes that could suggest herpes infection. It may also be used to confirm a diagnosis in people with suspected herpes who test negative for other types of tests. Additionally, it could be used in research or specialized clinical settings to track viral activity.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Test Results Mean

Positive results indicate the presence of HSV DNA, suggesting an active infection. Negative results mean no detectable viral genetic material was found in this sample. Results may vary depending on the stage of infection and testing sensitivity.

Common Reasons for Testing

This test is primarily used in research or specialized clinical settings to detect HSV DNA in blood. It may also be part of broader diagnostic workups for suspected herpes infections, especially in complex cases where other tests are inconclusive.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV DNA Test (Serum/Plasma)

Frequently asked questions

How often will I need this test?
This test is not routinely performed for routine herpes monitoring in most clinical settings. It may be used occasionally in research studies, specialized diagnostic scenarios, or if your healthcare provider suspects a specific type of herpes infection requiring detailed viral load assessment.
What are the typical reference ranges?
Reference ranges for this test are not standardized for routine clinical use. Results are qualitative (positive/negative) based on detection of HSV DNA, with no specific numeric thresholds provided.
Can I fast before this test?
No fasting is required for this blood test. However, always follow your healthcare provider’s instructions for any specific preparations.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy