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Herpes Simplex Virus (HSV) DNA Detection by Nucleic Acid Amplification (NAA) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of genetic material from the herpes simplex virus (HSV) in your blood, which may indicate an active infection.

Quick summary

["Helps diagnose herpes simplex virus infections in your bloodstream."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5014-6
Short code
HSV DNA Spec Ql NAA+probe
Synonyms
HSV DNA Spec Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fever, rash, or other signs of infection that could be caused by HSV, or if you have a suspected primary or recurrent herpes infection. It may also be used to monitor certain conditions or treatments related to HSV.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. The sample is collected in a tube that separates serum or plasma from blood cells for testing.

What the Test Involves

The test uses a specialized technique to detect tiny amounts of HSV DNA in your blood. This method amplifies the genetic material to identify if HSV is present, even in low concentrations.

What the Results Mean

Positive results indicate the presence of HSV DNA, suggesting an active infection. Negative results mean no detectable HSV DNA was found in your sample. Results can help guide treatment decisions and management of symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV DNA Test (Serum/Plasma)

Frequently asked questions

What does a positive result mean?
A positive result means HSV DNA was found in your blood, which may indicate an active herpes infection. This could be due to a primary infection (first-time exposure) or a reactivation of a latent infection. Your healthcare provider will discuss next steps, such as treatment options or further testing.
How soon will I get my results?
Results are typically available within a few days to a week, depending on your lab’s processing time. Your healthcare provider will contact you with the results and any follow-up instructions.
Can I take anything before the blood draw?
No special preparations are needed. However, inform your healthcare provider if you are on any medications, especially blood thinners, as they may affect your blood sample.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy