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Herpes Simplex Virus IgG Antibody (Serum/Plasma) – Quantitative

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies against herpes simplex virus (HSV) in your blood. These antibodies indicate past infection or immunity.

Quick summary

["Your body’s immune response to HSV over time."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9659-4
Short code
HSV IgG CSF IA-aCnc
Synonyms
HSV IgG CSF IA-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies specific to HSV, which develop after initial infection. These antibodies remain in your system long after the acute infection has resolved, helping your immune system recognize and fight future exposures. This is not a test for active infection but rather a marker of prior exposure.

Why Might You Need This Test?

Doctors may order this test if you have a history of HSV infections, suspect recurrent outbreaks, or need to confirm immunity before certain procedures (e.g., organ transplants, pregnancy). It can also help diagnose conditions like herpes encephalitis or monitor immune response in chronic cases.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw at a clinic or lab. If you’re pregnant, breastfeeding, or have a bleeding disorder, let your provider know before the test.

What to Expect During the Test

A healthcare professional will insert a small needle into a vein in your arm. You may feel a brief pinch, but the process usually takes only a few minutes. You can sit or lie down while it happens.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Antibody to HSV

Frequently asked questions

Will this test show if I have an active herpes infection?
No, this test only measures antibodies, which indicate past infection or immunity. For active herpes (viral shedding), you’d need a separate test like viral culture or PCR.
Can I get false results if I’ve recently been exposed to HSV?
Yes, it may take 1–3 weeks for IgG antibodies to develop after initial infection. If you suspect recent exposure, wait at least that long before testing.
Does this test help with pregnancy or newborn care?
Yes, it can confirm maternal immunity to HSV, which is important for preventing neonatal infections. If your levels are low, your provider may recommend antiviral treatment during pregnancy.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy