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Herpes Simplex Virus IgG Antibody (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the herpes simplex virus (HSV), which your immune system produces after being exposed to the virus. These antibodies indicate past infection or immunity.

Quick summary

["Past HSV exposure or immunity can be confirmed with this blood test."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44505-6
Short code
HSV IgG CSF Ql
Synonyms
HSV IgG CSF Ql
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies—part of your immune system’s response to HSV. These antibodies develop after an initial infection and can remain in your blood for years. This test is not used to diagnose current HSV infection but helps confirm past exposure or immunity.

Why Might You Need This Test?

Your healthcare provider may order this test if you have a history of HSV infection, are planning pregnancy, or have symptoms that suggest past exposure (e.g., recurrent cold sores, genital sores). It can also be used for screening in certain high-risk groups.

How Is the Test Performed?

A small blood sample is drawn from a vein in your arm. The sample is sent to a lab, where it is tested using an immunoassay method to identify HSV-specific antibodies.

What Are the Possible Results?

A positive result means your body has produced IgG antibodies to HSV, suggesting past infection. A negative result means no detectable antibodies were found, which may indicate no prior exposure or insufficient time since exposure for antibodies to develop.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV IgG Antibody

Frequently asked questions

What Does a Positive Result Mean?
A positive result means your immune system has recognized and fought HSV in the past, likely providing protection against future infections. This can be useful for planning pregnancy or managing chronic conditions linked to HSV.
What Does a Negative Result Mean?
A negative result suggests you may not have been exposed to HSV in the past or that antibodies have not yet developed (e.g., shortly after exposure). If you suspect HSV infection, further testing or clinical evaluation may be needed.
Can This Test Detect Active HSV Infection?
No, this test does not detect active HSV infection. If you have symptoms of a current outbreak (e.g., sores, pain), your provider may recommend additional testing or clinical assessment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy