Herpes Simplex Virus IgG Antibody (Serum/Plasma)
This test measures the presence of antibodies against the herpes simplex virus (HSV), a common virus that can cause cold sores or genital herpes. These antibodies indicate past infection or immunity.
["This test helps determine if you’ve been exposed to HSV or if your immune system has developed protection against it."]
Key facts at a glance
- LOINC
- 53533-6
- Short code
- HSV IgG Fld Ql IA
- Synonyms
- HSV IgG Fld Ql IA
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
Herpes simplex virus (HSV) is a highly contagious virus that can cause infections in the mouth, skin, or genital area. Once infected, the virus remains in your body and can reactivate later. This test detects IgG antibodies, which develop after an initial infection and can persist for years. IgG antibodies are a sign that your immune system has recognized and responded to the virus, but they don’t necessarily indicate whether you currently have an active infection.
Why It’s Done
Doctors may order this test if you have symptoms of HSV infection (such as sores, pain, or itching), a history of HSV, or if you’re being evaluated for conditions where HSV exposure is a concern (like pregnancy, organ transplants, or immune-compromised states). It can also be used to confirm past exposure or monitor immune response in certain medical settings.
What to Expect Before the Test
No special preparation is needed for this blood test. You may be asked to fast for 8–12 hours before the draw if your lab requires it, but this is not always the case. Bring any medications or supplements you’re taking, as some may affect test results.
What to Expect During the Test
A healthcare provider will draw blood from a vein in your arm. You may feel a slight pinch or discomfort, but it usually lasts only a few seconds. The process takes about 5 minutes, and you can resume normal activities afterward.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive IgG results suggest past HSV exposure and immunity, but they do not confirm an active infection. If you have symptoms of HSV (such as sores, flu-like symptoms, or recurrent outbreaks), additional testing (like HSV culture or PCR) may be needed to diagnose an active infection. This test is particularly important in high-risk groups, such as pregnant women, to assess potential transmission risks. It can also guide decisions about antiviral treatment or preventive measures.
Short name
IgG Antibody to HSV
Frequently asked questions
Can this test tell me if I currently have an active herpes infection?
What does a positive result mean for my health?
Could this test be affected by my medications or health conditions?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy