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Herpes Simplex Virus IgG Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against herpes simplex virus (HSV) in your blood. These antibodies indicate past exposure to HSV-1 or HSV-2, which can cause cold sores or genital herpes.

Quick summary

["Past infection with HSV may be detected through antibody testing, even if you don’t currently have symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109768-2
Short code
HSV IgG Msmt CSF
Synonyms
HSV IgG Msmt CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Herpes simplex virus (HSV) is a common virus that can cause cold sores (HSV-1) or genital herpes (HSV-2). This test detects IgG antibodies, which develop after your body has encountered the virus. IgG antibodies stay in your blood for years, even after the active infection has cleared.

Why Might Your Doctor Order This Test?

Your doctor may recommend this test if you have had symptoms of HSV, such as sores or lesions, or if you have a history of recurrent outbreaks. It can also be used to confirm past infection in people who never had symptoms or in cases where active infection testing is inconclusive.

What Does a Positive Result Mean?

A positive result means your blood contains IgG antibodies to HSV, suggesting you have been exposed to the virus at some point. This does not indicate whether you currently have an active infection or if you are contagious.

What Does a Negative Result Mean?

A negative result means your blood does not currently show detectable IgG antibodies to HSV. This could mean you have never been exposed to the virus or that your body has not yet produced detectable antibodies.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Understanding Your Results

Short name

IgG Antibody to HSV (Herpes Simplex Virus)

Frequently asked questions

How long after exposure might I develop detectable antibodies?
IgG antibodies typically develop within 2 to 6 weeks after initial exposure to HSV. However, it can take longer for some people. If you suspect recent exposure, your doctor may recommend additional testing for active infection (such as viral culture or PCR) to confirm current status.
Can this test differentiate between HSV-1 and HSV-2?
This test detects antibodies to both HSV-1 and HSV-2. To distinguish between the two, your doctor may use additional testing, such as viral culture or PCR, or a different antibody test targeting specific strains.
If I have a positive result, does that mean I will always have HSV?
A positive IgG result indicates past exposure but does not guarantee ongoing infection. Many people with HSV-1 or HSV-2 have no active symptoms and do not experience outbreaks. However, some may have recurring symptoms, and the virus can remain dormant in your body.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy