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Herpes Simplex Virus (HSV) IgG Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against the herpes simplex virus (HSV), which can help determine past exposure to the virus.

Quick summary

["This test helps identify if you’ve ever been exposed to HSV, a common virus that can cause cold sores or genital herpes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110967-7
Short code
HSV IgG Msmt Ser
Synonyms
HSV IgG Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The HSV IgG antibody test detects specific proteins (antibodies) your immune system produces in response to past infection by HSV. These antibodies remain in your blood for years after the initial infection, even if you don’t currently have symptoms.

Why Might You Need This Test?

Doctors may order this test if you have recurring cold sores or genital herpes symptoms, if you’ve been exposed to someone with HSV, or if you’re evaluating for latent infection (when the virus is inactive but still present). It can also be used during pregnancy to assess risk for transmission to a baby.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The serum portion is then tested for HSV IgG antibodies using an immunoassay method, which identifies the antibodies without requiring active viral presence.

What Are the Results Typically Used For?

Positive results indicate past exposure to HSV, but they don’t confirm whether the virus is currently active. Negative results mean you likely haven’t been exposed recently, though a latent infection could still exist undetected.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance:

Short name

HSV IgG Antibody

Frequently asked questions

How Does This Test Help in Diagnosis or Management?
While HSV IgG tests are useful for ruling out recent infection, they’re not definitive for active herpes outbreaks. If you suspect an active infection, your doctor may recommend additional testing or observation of symptoms.
Can This Test Be Used During Pregnancy?
Yes, HSV IgG testing can be part of prenatal care to assess risk for neonatal herpes transmission. However, active herpes lesions during pregnancy require immediate medical evaluation and treatment.
What If My Results Are Positive?
A positive result means you’ve likely had HSV at some point. If you’re concerned about transmission to others or partners, discuss this with your healthcare provider for guidance on precautions or further testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy