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Herpes Simplex Virus IgG Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the herpes simplex virus (HSV) in your blood, indicating past or ongoing infection by HSV-1 or HSV-2.

Quick summary

["Helps determine if you’ve been exposed to herpes and whether the virus may be active in your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
52981-8
Short code
HSV IgG Ser IA-aCnc
Synonyms
HSV IgG Ser IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects IgG antibodies, a type of immune protein your body produces in response to past exposure to HSV. These antibodies stay in your system long after the initial infection has resolved, marking your immune system’s memory of the virus.

Why It’s Done

Doctors may order this test if you have symptoms like sores, pain, or recurrent outbreaks, or if you’re at higher risk (e.g., sexually active, pregnant, or with weakened immunity). It can also help confirm a diagnosis when other tests are inconclusive.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, typically drawn from your arm. The test is usually done in a lab and results are ready within a few days.

What the Results Mean

Positive results mean you likely had HSV at some point, but they don’t always indicate whether the virus is currently active. Negative results suggest no detectable antibodies, meaning either you’ve never been exposed or the test was taken too early.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Antibody to HSV (Herpes Simplex Virus)

Frequently asked questions

Why might my doctor ask for this test?
Your doctor may recommend this test to diagnose herpes, assess risk for transmission, or evaluate symptoms like recurrent sores or neurological issues (e.g., herpes zoster). It’s also used in pregnancy to screen for HSV-2, which can affect the baby.
What does a positive result mean for my health?
A positive result means you’ve been exposed to HSV, but it doesn’t tell you if the virus is active. If you have symptoms, your doctor may recommend antiviral treatment to manage outbreaks or reduce transmission.
Can I get this test at home?
No, this test requires a blood sample from a healthcare provider. Some clinics offer at-home blood draws, but results are typically processed in a lab.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy