Skip to content

Herpes Simplex Virus IgG Antibody (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies in your blood that your immune system produces in response to the herpes simplex virus (HSV). It helps determine if you’ve been exposed to HSV at some point in your life.

Quick summary

["This test checks for past infection with HSV, the virus responsible for cold sores and genital herpes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
20446-1
Short code
HSV IgG Ser IA-Imp
Synonyms
HSV IgG Ser IA-Imp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms like sores, pain, or unusual rashes that could be caused by HSV. They might also recommend it if you have a history of HSV or are at higher risk for infection, such as during pregnancy or if you have a weakened immune system.

What to Expect Before the Test

No special preparation is needed for this blood test. You may have a small needle inserted into your arm to draw blood, which usually takes just a few minutes. If you’re nervous, let your provider know so they can help make it more comfortable.

What the Test Results Mean

A positive result means your body has produced antibodies against HSV, indicating past exposure. A negative result suggests you haven’t developed these antibodies, meaning you likely haven’t been exposed to HSV in the past. However, a negative result doesn’t guarantee you’re currently free of the virus.

Possible Results and Next Steps

If your result is positive, your provider may recommend further testing to check for active infection (like HSV culture or PCR) or monitor symptoms. If negative, they might still check for current infection if you have active symptoms or risk factors.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is important for diagnosing past HSV infection, which can help guide treatment decisions, especially during pregnancy or in individuals with weakened immune systems. It can also help prevent transmission by confirming exposure history.

Short name

IgG Antibody to HSV

Frequently asked questions

What does a positive result mean?
A positive result means your immune system has detected HSV antibodies, indicating you’ve likely been exposed to the virus at some point. This doesn’t mean you currently have an active infection, but it confirms past exposure.
Can I get HSV even if my test is negative?
Yes, a negative result only means your body hasn’t produced detectable antibodies against HSV at the time of testing. You could still be infected with the virus without developing antibodies, especially if your infection is recent or your immune system is compromised.
How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on your lab’s processing time. Your provider will contact you once they have the results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy