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Herpes Simplex Virus IgG Antibody (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the herpes simplex virus (HSV), which your immune system produces after being exposed to the virus. These antibodies indicate past infection, even if you no longer have active symptoms.

Quick summary

["Past HSV exposure may affect future health or treatment options."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40728-8
Short code
HSV IgG Ser Ql IA
Synonyms
HSV IgG Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies specific to HSV, a type of antibody your body makes in response to infection. These antibodies are produced months to years after initial exposure and can persist long-term. The presence of these antibodies suggests your immune system has encountered HSV, but they do not confirm an active infection at the time of testing.

Why Might You Need This Test?

Doctors may order this test if you have a history of HSV infection, recurrent cold sores, or if you’re being evaluated for conditions where HSV exposure could be relevant, such as certain immune disorders or pregnancy-related considerations.

What Does a Positive Result Mean?

A positive result means your body has produced IgG antibodies against HSV, indicating past exposure. This does not mean you currently have an active infection, but it confirms your immune system has been exposed to the virus.

What Does a Negative Result Mean?

A negative result suggests you have not been exposed to HSV through antibodies detected in this test. However, this does not rule out possible past exposure without antibody presence or an active infection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG HSV Antibody

Frequently asked questions

How long after exposure might antibodies appear?
IgG antibodies typically develop 2–12 weeks after initial HSV exposure and can remain detectable for years. If you suspect recent exposure, other tests (like HSV PCR) may be needed for active infection confirmation.
Can this test differentiate between HSV-1 and HSV-2?
No, this test only identifies HSV antibodies broadly. To distinguish between HSV-1 or HSV-2, additional specific antibody tests (e.g., IgG HSV-1 or HSV-2) would be required.
What if my symptoms suggest an active HSV infection?
If you have active symptoms (e.g., sores, pain, or flu-like illness), your doctor may recommend a different test, such as viral culture or PCR, to confirm an active HSV infection rather than just past exposure.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy