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Herpes Simplex Virus Immunoglobulin G (IgG) Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies in your blood that your immune system produces in response to the herpes simplex virus (HSV). These antibodies help your body recognize and fight the virus if it becomes active later.

Quick summary

["This test helps determine if you’ve ever been exposed to HSV, even if you don’t currently have symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53377-8
Short code
HSV IgG Titr Ser
Synonyms
HSV IgG Titr Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82977
SNOMED
3110003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test looks for **IgG antibodies** specific to HSV, which develop after initial infection. Unlike IgM antibodies (which appear shortly after infection), IgG antibodies can remain in your blood for years, indicating past exposure. This test is not used to diagnose an active HSV infection but rather to assess long-term immunity or exposure history.

Why Might You Need This Test?

Your healthcare provider may recommend this test if you have a history of HSV infection, are planning pregnancy (to check for past exposure), or if you’re evaluating symptoms that could be related to past viral exposure—though active infection would require different testing.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The serum (liquid part of blood) is then tested using an **immunoassay** method to detect HSV-specific IgG antibodies. Results are reported as positive or negative, or sometimes as a quantitative value indicating antibody level.

What Do Results Mean?

A **positive result** means your body has produced HSV IgG antibodies, suggesting past exposure to the virus. A **negative result** means no detectable antibodies were found, though this doesn’t rule out very early or recent infection. Consult your provider for interpretation based on your medical history.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Antibody to HSV

Frequently asked questions

Can this test tell me if I currently have an active HSV infection?
No. This test only detects antibodies from past exposure. For diagnosing an active infection, your provider may order a different test, such as viral culture or PCR, which looks for the virus itself in your body fluids.
What does a ‘positive’ result mean for my health?
A positive result means your immune system has recognized HSV at some point. While this doesn’t affect your current health directly, it may be relevant if you’re planning pregnancy, have a weakened immune system, or are being evaluated for conditions linked to past viral exposure (e.g., certain cancers or neurological disorders). Always discuss results with your healthcare provider.
How long do HSV IgG antibodies stay in my blood?
IgG antibodies from HSV can persist for years or even decades after initial infection. Some people may still have detectable levels even after many years, while others may lose them over time. Your provider can help clarify this based on your medical history and test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy