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Herpes Simplex Virus Immunoglobulin G (IgG) Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies to the herpes simplex virus type 1 or 2 (HSV-1 or HSV-2) in your blood. Antibodies are your body’s natural defense against infections.

Quick summary

["This test helps determine if you’ve ever been exposed to herpes simplex virus and may have developed immunity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111360-4
Short code
HSV IgM Msmt Ser
Synonyms
HSV IgM Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies, which develop after an initial infection with HSV. These antibodies stay in your blood for years, indicating past exposure rather than an active infection. Unlike IgM antibodies, which appear shortly after infection, IgG antibodies are a marker of long-term immunity.

Why Might Your Doctor Order This Test?

Your doctor may recommend this test if you have symptoms suggestive of herpes (e.g., sores, pain, or recurrent outbreaks), a history of herpes, or if you’re evaluating for past exposure in certain medical or pregnancy contexts.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. The process usually takes a few minutes, and you may feel slight discomfort.

What to Expect After the Test

After the blood is drawn, you’ll need to rest for a few minutes. Apply gentle pressure to the site to stop bleeding. There may be mild bruising or soreness, but this typically resolves quickly.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV IgG Antibody

Frequently asked questions

Can this test tell me if I currently have herpes?
No, this test only shows if you’ve ever been exposed to HSV and developed antibodies. For active herpes, your doctor may order additional tests.
What does a positive result mean for my health?
A positive result means your body has developed immunity to HSV, but it does not affect your current health status. If you’ve had symptoms, further testing may be needed to confirm active infection.
Can I get tested if I’ve never had symptoms?
Yes, if you have a history of herpes exposure, are pregnant, or have risk factors (e.g., sexual history), this test can help assess immunity. Always discuss your reasons for testing with your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy