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High-Sensitivity C-Reactive Protein (hsCRP) by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein called C-reactive protein (CRP), which your body produces in response to inflammation. CRP levels can help doctors assess whether you have low-grade inflammation, which may be linked to conditions like heart disease or autoimmune disorders.

Quick summary

["hsCRP helps track subtle inflammation in your body, often used alongside other tests to guide preventive care or treatment planning."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5857-8
Short code
HSV Islt IF
Synonyms
HSV Islt IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is hsCRP Used For?

hsCRP is primarily used to monitor low-level inflammation in the body. Doctors may order this test to evaluate risk for cardiovascular diseases, assess response to treatments for inflammatory conditions, or check for signs of infection or autoimmune activity when other tests are inconclusive.

How Is This Test Performed?

A blood sample is drawn from a vein in your arm. The sample is processed to separate serum (the liquid part) and then analyzed using a sensitive immunoassay method to detect CRP levels. Results are reported in milligrams per liter (mg/L).

What Does a High or Low hsCRP Level Mean?

Elevated hsCRP levels may indicate chronic, low-grade inflammation, which can contribute to conditions like atherosclerosis or arthritis. Very low levels suggest minimal inflammation. However, results alone don’t diagnose a specific condition; they’re often part of a broader evaluation.

Common Conditions Monitored with hsCRP

hsCRP is commonly used to monitor heart disease risk, track inflammation in conditions like rheumatoid arthritis or lupus, or evaluate responses to treatments that target inflammation. It’s also sometimes used in research or specialized care plans.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: hsCRP plays a key role in identifying systemic inflammation that may not be obvious through other tests. While not a definitive diagnostic tool, it helps doctors tailor preventive care, monitor chronic conditions, or adjust treatments for patients with suspected inflammatory processes.

Short name

hsCRP

Frequently asked questions

Why might my doctor order an hsCRP test?
Your doctor may recommend an hsCRP test if you have risk factors for heart disease, are undergoing treatment for an inflammatory condition, or if they suspect low-grade inflammation without a clear cause. It’s also sometimes used as a screening tool in certain populations.
What are typical reference ranges for hsCRP?
Reference ranges vary by lab and patient factors. Generally, very low levels (below 1 mg/L) suggest minimal inflammation, while moderate to high levels (above 3 mg/L) may indicate increased risk for cardiovascular issues or active inflammation. Your specific results should be discussed with your healthcare provider.
Can lifestyle changes affect hsCRP levels?
Yes, lifestyle factors like diet, exercise, smoking, and stress can influence inflammation. Improving these habits may lower hsCRP levels over time, potentially reducing inflammation-related risks. Always discuss personal lifestyle changes with your doctor before making significant adjustments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy