Herpes Simplex Virus (HSV) Serology, Qualitative (IgG) by Immunoassay
This test checks for antibodies to the herpes simplex virus (HSV), which your immune system produces in response to past infection with HSV-1 or HSV-2. Antibodies indicate exposure to the virus, but not whether you currently have an active infection.
["This test helps determine if you’ve been exposed to herpes simplex virus in the past."]
Key facts at a glance
- LOINC
- 62454-4
- Short code
- HSV+VZV Spec Cult
- Synonyms
- HSV+VZV Spec Cult
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- organism-specific-culture
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test detects specific antibodies (IgG) produced by your immune system after exposure to HSV. These antibodies are a sign that your body has encountered the virus, but they don’t indicate whether you have an active infection at the time of testing. IgG antibodies remain in your blood for years after infection.
How the Test Works
This is an immunoassay test, which uses a chemical reaction to identify the presence of HSV antibodies in your serum. The method detects IgG antibodies, which are typically present months to years after initial infection.
Why It’s Done
Doctors may order this test to assess past exposure to HSV, especially if you have a history of herpes outbreaks, recurrent infections, or if you’re evaluating for latent infection (when the virus is inactive but still present). It’s also used in certain medical or research settings to monitor immune response.
What to Expect Before the Test
No special preparation is needed. You may have a blood draw at a clinic, hospital, or lab. If you’re taking blood from your own arm, use an antiseptic wipe to clean the area and follow the instructions provided.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
HSV IgG Antibody Test
Frequently asked questions
Why might this result matter?
What does a positive result mean?
Can this test be used to diagnose active herpes?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy