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Herpes Simplex Virus (HSV) Serology, Qualitative (IgG) by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the herpes simplex virus (HSV), which your immune system produces in response to past infection with HSV-1 or HSV-2. Antibodies indicate exposure to the virus, but not whether you currently have an active infection.

Quick summary

["This test helps determine if you’ve been exposed to herpes simplex virus in the past."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
62454-4
Short code
HSV+VZV Spec Cult
Synonyms
HSV+VZV Spec Cult
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
organism-specific-culture
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific antibodies (IgG) produced by your immune system after exposure to HSV. These antibodies are a sign that your body has encountered the virus, but they don’t indicate whether you have an active infection at the time of testing. IgG antibodies remain in your blood for years after infection.

How the Test Works

This is an immunoassay test, which uses a chemical reaction to identify the presence of HSV antibodies in your serum. The method detects IgG antibodies, which are typically present months to years after initial infection.

Why It’s Done

Doctors may order this test to assess past exposure to HSV, especially if you have a history of herpes outbreaks, recurrent infections, or if you’re evaluating for latent infection (when the virus is inactive but still present). It’s also used in certain medical or research settings to monitor immune response.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw at a clinic, hospital, or lab. If you’re taking blood from your own arm, use an antiseptic wipe to clean the area and follow the instructions provided.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV IgG Antibody Test

Frequently asked questions

Why might this result matter?
A positive result means your body has produced antibodies to HSV, suggesting past exposure. However, this does not confirm an active infection. If you’re concerned about current symptoms (like sores, pain, or flu-like illness), your doctor may recommend additional testing or evaluation. This test is not used to diagnose active herpes outbreaks but can help guide further medical decisions.
What does a positive result mean?
A positive result indicates your immune system has likely encountered HSV in the past, but it doesn’t tell you which type of HSV (HSV-1 or HSV-2) you had or if you currently have an active infection. If you have symptoms suggestive of an active infection, your doctor may order additional tests.
Can this test be used to diagnose active herpes?
No, this test is not used to diagnose an active herpes infection. If you suspect you have an active herpes outbreak, your doctor may recommend testing for viral DNA (via PCR) or viral culture to confirm an active infection.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy