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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and globulin proteins essential for maintaining fluid balance, immune function, and tissue repair.

Quick summary

["Total protein helps assess overall health and detect conditions like malnutrition, kidney disease, or liver problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40822-9
Short code
HTLV I Ab CSF Ql
Synonyms
HTLV I Ab CSF Ql
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Matters

Blood proteins play key roles in your body’s health. High levels might suggest dehydration, inflammation, or certain cancers, while low levels could indicate malnutrition, liver disease, or kidney problems. Your doctor may order this test to monitor chronic conditions or investigate unexplained symptoms like swelling or fatigue.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm for a simple blood draw. Avoid heavy meals or alcohol 24 hours before if instructed, as they may affect results.

Common Conditions Monitored

Doctors use total protein to diagnose or track conditions like chronic kidney disease, liver disease (e.g., cirrhosis), malnutrition, or certain cancers (e.g., multiple myeloma). It can also help evaluate fluid balance in patients with heart or kidney issues.

What Your Results Mean

Results are compared to a general reference range (typically 6.4–8.3 g/dL), but individual ranges may vary. Very high or low values may signal underlying health concerns that need further investigation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

What could cause abnormal results?
High total protein might be due to dehydration, chronic inflammation, or conditions like multiple myeloma. Low levels often result from malnutrition, liver disease, kidney failure, or excessive protein loss (e.g., from burns or kidney disease). Always discuss results with your healthcare provider.
How often is this test repeated?
Your doctor will determine frequency based on your health needs. Some patients get this test annually or more often if managing chronic conditions like kidney or liver disease.
Does diet affect this test?
Yes, protein-rich foods can temporarily raise protein levels. Avoid heavy protein intake 24 hours before testing if instructed by your provider, but follow their guidance for accuracy.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy