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Antibody to Hepatitis B Virus Surface Antigen (IgG) – Serum

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies that your immune system produces in response to the hepatitis B virus surface antigen, a marker of past or potential immunity to hepatitis B.

Quick summary

["Assesses immunity to hepatitis B infection through IgG antibodies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14225-7
Short code
HTLV II g46 Ab Ser Ql
Synonyms
HTLV II g46 Ab Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects IgG antibodies against the hepatitis B surface antigen (HBsAg), which your body creates after exposure to the hepatitis B virus or vaccination. These antibodies indicate immunity and long-term protection against hepatitis B infection.

Why It’s Done

Doctors may order this test to confirm immunity after vaccination, screen for past infection, or evaluate immune response in individuals at risk of hepatitis B (e.g., healthcare workers, travelers, or those with multiple sexual partners).

Sample Collection

A blood sample is drawn from a vein in your arm. The serum portion is separated and sent to the lab for analysis.

What to Expect

You may feel slight discomfort from the needle, but most people tolerate blood draws well. Avoid alcohol for 24 hours before testing if instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Anti-HBs

Frequently asked questions

Positive results (detectable IgG antibodies) suggest immunity from vaccination or prior infection, reducing risk of hepatitis B. Negative results mean no detectable immunity and require further evaluation (e.g., hepatitis B surface antigen testing).
This test alone cannot confirm acute infection; it only shows past exposure or vaccination status.
If you’re vaccinated, a positive IgG Anti-HBs result means you’re likely protected for life. If negative, discuss booster recommendations with your healthcare provider.
If you’re unsure about your hepatitis B status, this test helps determine whether you should get vaccinated or screened for active infection.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy