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Antibody to Hepatitis B Surface Antigen (IgG) - Serum

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the hepatitis B surface antigen, which may indicate past or current immunity to hepatitis B virus (HBV).

Quick summary

["Measures your immune response to hepatitis B protection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44538-7
Short code
HTLV I+II Ab Ser Donr Ql
Synonyms
HTLV I+II Ab Ser Donr Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies against the hepatitis B surface antigen (HBsAg), a protein on the surface of the hepatitis B virus. These antibodies suggest your body has either been exposed to the virus in the past or has developed immunity through vaccination. IgG antibodies are typically long-lasting and provide protection.

Why Might You Need This Test?

Your healthcare provider may order this test to evaluate immunity status after vaccination, screen for past HBV infection, or assess exposure risk in certain clinical scenarios.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The blood is processed to separate serum, which is then tested for the presence of IgG antibodies. This test is typically performed on serum.

What to Expect Before the Test

No special preparation is needed. You may have a slight bruise or discomfort at the injection site, but this usually resolves quickly. Avoid eating or drinking for a short time before the draw if instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Anti-HBs

Frequently asked questions

What does a positive result mean?
A positive result means your immune system has produced IgG antibodies against the hepatitis B surface antigen, indicating either past infection with immunity or vaccination-induced immunity. This provides long-term protection against hepatitis B.
What if my test result is negative?
A negative result means your body did not produce detectable IgG antibodies at this time. This could mean you have never been exposed to the virus or your immunity is not yet detectable. Follow-up testing or vaccination may be recommended depending on your risk factors.
How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on your lab’s processing schedule. Your healthcare provider will discuss the results with you during your follow-up visit.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy