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Serum or Plasma Immunoassay for Total Bilirubin

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin in your blood, a yellow pigment produced when red blood cells break down. It helps assess liver function and detect conditions like jaundice or bile duct blockages.

Quick summary

["Bilirubin levels can signal liver or bile flow issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14019-4
Short code
HTLV I+II gp46 Ab SerPl Ql IB
Synonyms
HTLV I+II gp46 Ab SerPl Ql IB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Bilirubin is a waste product from hemoglobin breakdown, which normally passes through the liver into bile. High levels may indicate liver disease, gallbladder problems, or blood disorders. Low levels are less commonly significant but can sometimes reflect liver dysfunction or certain genetic conditions.

What to Expect Before the Test

You’ll likely have a simple blood draw from a vein in your arm. No special preparation is needed unless your doctor instructs otherwise. If you’re on blood thinners, let your lab staff know to avoid excessive bruising.

Common Conditions Monitored

Doctors use this test to diagnose or monitor conditions like hepatitis, cirrhosis, gallstones, hemolytic anemia, or newborn jaundice. It may also be checked after liver surgery or during chemotherapy for blood-related cancers.

What the Results Mean

Results are typically reported in milligrams per deciliter (mg/dL). Elevated levels may trigger further testing for liver function or bile flow. Your doctor will interpret results in the context of your overall health and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Elevated bilirubin often points to impaired liver function or bile obstruction, while very low levels may rarely suggest liver disease or genetic disorders. Always discuss results with your healthcare provider.

Short name

Total Bilirubin

Frequently asked questions

Will this test hurt?
A blood draw may cause mild discomfort or bruising at the site, but most people tolerate it well. If you’re anxious, ask your doctor about numbing cream or other options.
How often will I need this test?
Frequency depends on your health condition. Some patients get it monthly, others yearly. Your doctor will schedule it based on your treatment plan or symptoms.
Can I eat or drink before the test?
No fasting is required unless your doctor specifies. However, avoid alcohol or certain medications that may affect liver function before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy