Skip to content

Antibody to Hepatitis B Core Antigen (IgG) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the hepatitis B core antigen, which can indicate past or potential exposure to hepatitis B virus (HBV).

Quick summary

["Helps determine if you’ve been exposed to hepatitis B or if your body has developed immunity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44874-6
Short code
HTLV I+II RNA Ser Ql NAA+probe
Synonyms
HTLV I+II RNA Ser Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects IgG antibodies against the hepatitis B core antigen. These antibodies appear after your body has encountered the virus, either through infection or vaccination. IgG antibodies typically persist long-term, marking immunity rather than an active infection.

Why It’s Ordered

Your healthcare provider may order this test if you have risk factors for hepatitis B (e.g., travel to regions with high HBV prevalence, sexual history, or exposure to infected blood), unexplained liver issues, or if you’re vaccinated but still want reassurance.

When Results May Be Abnormal

While IgG antibodies alone don’t confirm active hepatitis B, they suggest past infection or immunity. Results may be used alongside other tests (like hepatitis B surface antigen) to assess your health status.

What to Expect Before the Test

No special preparation is needed. A blood sample is drawn from a vein, similar to other routine blood tests. You may feel slight discomfort, but it’s brief.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Understanding Your Results

Short name

Anti-HBc IgG (Hepatitis B Core Antibody IgG)

Frequently asked questions

How long do I need to wait for my results?
Results are typically available within 1–3 business days, depending on lab processing times. Your provider will discuss them with you during a follow-up visit.
Can this test detect acute hepatitis B?
No, this test alone cannot distinguish between past infection or immunity from acute (current) hepatitis B. It’s often used alongside other markers (like hepatitis B surface antigen) for a full picture.
What if my test is positive for anti-HBc IgG?
A positive result means you’ve likely had hepatitis B at some point or received the vaccine. Your provider may recommend further testing (e.g., hepatitis B surface antibody) to confirm immunity or check for chronic infection.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy