Genetic analysis for mutations in the HTR2A and HTR2C genes (serum/plasma DNA)
This test checks for specific genetic variations in the HTR2A and HTR2C genes, which are linked to serotonin receptor function. These genes can influence how your body responds to serotonin, a chemical messenger that affects mood, sleep, and other functions.
["This test helps identify potential genetic factors that may influence conditions related to serotonin signaling."]
Key facts at a glance
- LOINC
- 46726-6
- Short code
- HTR2A+HTR2C gene Mut Anl Bld/T
- Synonyms
- HTR2A+HTR2C gene Mut Anl Bld/T
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have a family history of psychiatric conditions like depression, anxiety, or schizophrenia, or if you have symptoms that could be linked to serotonin-related disorders. It may also be considered for research purposes or if you’re exploring genetic testing for unexplained symptoms.
What the Test Measures
The test analyzes DNA extracted from a blood sample to detect mutations in the HTR2A and HTR2C genes. These genes encode proteins involved in serotonin signaling, which can affect how your brain processes mood-regulating chemicals.
Sample Collection and Processing
A small blood sample is drawn from your arm. The blood is processed to isolate DNA, which is then tested for specific genetic variations. This process typically takes a few days to complete, depending on laboratory procedures.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to avoid certain medications or foods for a short time if instructed by your provider. If you’re taking antidepressants or other medications that affect serotonin, discuss this with your doctor before testing.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Genetic screening for serotonin receptor genes
Frequently asked questions
Genetic mutations in HTR2A or HTR2C may influence your risk for conditions like depression, anxiety, or other serotonin-related disorders. While these findings can provide insights into your genetic profile, they are not definitive diagnoses. They may help guide treatment options, such as medication choices or lifestyle strategies.
How long will I need to wait for results?
Will this test affect my insurance coverage?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy