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Cerebrospinal Fluid Total Protein by Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). Proteins in CSF can help identify conditions affecting the central nervous system.

Quick summary

["Protein levels in CSF may signal inflammation, infection, or other neurological issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16139-8
Short code
Hu Ab Titr CSF
Synonyms
Hu Ab Titr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like headaches, neck stiffness, vision changes, or neurological problems. It’s also used to diagnose conditions such as meningitis, multiple sclerosis, or brain tumors.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your lumbar spine to collect a small sample of CSF. The procedure is quick and usually painless, though you may feel mild pressure or discomfort.

What the Results Mean

Higher-than-normal protein levels might suggest inflammation, infection, or a breakdown of the blood-brain barrier. Lower-than-normal levels could indicate certain neurological disorders or bleeding in the brain.

Common Conditions Linked to Abnormal Results

Elevated protein levels can be seen in conditions like Guillain-Barré syndrome, multiple sclerosis, or subarachnoid hemorrhage. Low protein levels may be associated with conditions like hydrocephalus or certain brain injuries.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Total Protein (Electrophoresis)

Frequently asked questions

How is CSF collected for this test?
CSF is collected through a procedure called a lumbar puncture (spinal tap), where a needle is inserted into the lower back to draw a small sample of fluid from the spinal canal.
What does a normal CSF protein level indicate?
A normal CSF protein level suggests there is no significant inflammation, infection, or disruption in the blood-brain barrier. However, individual results depend on the clinical context and other test findings.
Can diet or medications affect CSF protein levels?
Dietary factors or certain medications may indirectly influence overall health, but they rarely directly affect CSF protein levels. Your doctor will consider all relevant factors when interpreting results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy