Skip to content

Hydroxyproline in Urine (Free)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of hydroxyproline, a breakdown product of collagen, in your urine. It helps assess collagen metabolism and may be used to monitor conditions affecting connective tissue.

Quick summary

["Hydroxyproline in urine can help track collagen-related health and certain metabolic processes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14782-7
Short code
HVA Ur-sCnc
Synonyms
HVA Ur-sCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to evaluate collagen breakdown, monitor collagen-related disorders, or assess kidney function. It can also be part of research studies or specialized diagnostic workups for conditions like osteoporosis, scurvy, or certain metabolic diseases.

What to Expect Before the Test

No special preparation is needed. You’ll provide a urine sample, typically collected over a 24-hour period or a single random sample. If timed, follow your doctor’s instructions for timing and collection.

What the Results Mean

Hydroxyproline levels can vary based on diet, hydration, and underlying health. Elevated levels may suggest increased collagen breakdown, while lower levels could indicate reduced collagen synthesis or kidney issues. Results are interpreted by your healthcare provider in the context of your medical history.

Common Conditions Monitored

This test is often used to monitor conditions like osteoporosis, scurvy, or collagen-related disorders. It may also help diagnose or track kidney disease or metabolic disorders affecting collagen metabolism.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Free Hydroxyproline Urine

Frequently asked questions

What does a high or low hydroxyproline level mean?
A high level might suggest increased collagen breakdown, which could be linked to conditions like kidney disease, osteoporosis, or certain metabolic disorders. A low level could indicate reduced collagen production or kidney issues. Your doctor will discuss these findings with you based on your overall health.
How is this test different from other collagen-related tests?
Unlike blood tests for collagen proteins (e.g., procollagen), this test measures hydroxyproline, a breakdown product found in urine. It provides insight into collagen metabolism but isn’t the same as measuring intact collagen in blood.
Can diet affect hydroxyproline levels?
Yes, diet can influence hydroxyproline levels. High-protein diets or certain supplements may temporarily alter urine hydroxyproline. Your doctor may ask you to follow a specific diet or timing protocol before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy