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Urine Hydrocodone Mass Concentration (24-Hour Collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of hydrocodone, a semi-synthetic opioid pain reliever, in your urine over a 24-hour period. It helps assess recent opioid use, adherence to treatment, or exposure to the drug.

Quick summary

["This test helps track opioid exposure or compliance with prescribed medication."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51738-3
Short code
HYDROcodone Free Ur-mCnc
Synonyms
HYDROcodone Free Ur-mCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you’re taking hydrocodone (e.g., Vicodin) or if you’re suspected of using opioids for non-medical reasons. It’s also used in drug testing programs, pain management evaluations, or to monitor recovery from opioid dependence.

What to Expect Before the Test

You’ll need to collect all urine produced in a 24-hour period in a special container. Follow your healthcare provider’s instructions carefully to ensure accurate results. Avoid drinking excessive fluids that could dilute the sample.

How the Test Works

The collected urine is analyzed using a sensitive laboratory method to detect and quantify hydrocodone. The test measures the total amount of the drug present, not just active metabolites.

What the Results Mean

Results are reported as the total mass of hydrocodone in your urine over 24 hours. Higher levels may indicate recent opioid use, improper dosing, or potential misuse. Your doctor will interpret results in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Urine Hydrocodone (24h)

Frequently asked questions

What does a positive result mean?
A positive result suggests recent exposure to hydrocodone, which could be due to prescribed medication, recreational use, or other sources. This may prompt further evaluation by your doctor to assess risk, adherence, or underlying issues like addiction.
How often should I get this test?
The frequency depends on your treatment plan. If you’re prescribed hydrocodone, your doctor may recommend periodic testing to monitor use or adjust your medication as needed. Follow their guidance, as testing intervals vary widely.
Can I drink alcohol before this test?
Alcohol itself won’t affect the test results, but it may interact with hydrocodone. If you’re taking this medication, avoid alcohol to reduce the risk of side effects like drowsiness or slowed breathing. Always check with your doctor first.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy