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Serum/plasma concentration of proteinaceous substances detected by nephelometry (e.g., total protein, albumin, globulins)

Published: August 9, 2026Updated: August 16, 2026

This test measures key protein levels in your blood, including albumin and globulins, which help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Protein levels can signal health issues like malnutrition, kidney disease, or liver problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1008-2
Short code
IAT Poly-Sp Reag SerPl Ql
Synonyms
IAT Poly-Sp Reag SerPl Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test to check for conditions affecting protein production, such as liver disease, kidney problems, or nutritional deficiencies. It can also help monitor chronic illnesses like heart failure or certain autoimmune disorders.

What to Expect Before the Test

No special preparation is needed, but avoid eating or drinking for 8–12 hours before the draw if instructed. Wear a loose shirt for easy access to your arm.

What Happens During the Test

A healthcare provider will insert a small needle into your vein to draw blood. You may feel a brief pinch, but it’s usually over quickly. The blood is then sent to a lab for analysis.

What the Results Mean

Results help identify imbalances in protein levels, which can indicate underlying health concerns. Abnormal findings may prompt further testing or treatment adjustments.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Low protein levels (hypoproteinemia) may signal malnutrition, liver disease, or kidney failure, while high levels (hyperproteinemia) could suggest dehydration, multiple myeloma, or inflammation. Monitoring these levels is critical for diagnosing and managing conditions like cirrhosis, chronic kidney disease, or severe infections.

Short name

Total Protein Profile (Nephelometry)

Frequently asked questions

What causes abnormal protein test results?
Abnormal results can stem from conditions like liver disease (reduced albumin), kidney disease (protein loss in urine), infections, or certain cancers (e.g., multiple myeloma). Lifestyle factors like poor nutrition or excessive protein intake may also play a role.
How often should I get this test?
Your doctor will determine frequency based on your health needs—some patients need it monthly, while others may only require it annually or as needed for monitoring.
Can diet affect protein test results?
Yes, diet can influence protein levels. High-protein diets or deficiencies may shift results, so follow your doctor’s advice on timing and preparation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy