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Serum IgA Electrophoresis (Quantitative Protein Profile)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin A (IgA), a type of antibody protein, in your serum using electrophoresis. It helps assess protein distribution in blood, often used to evaluate conditions affecting protein levels or immune function.

Quick summary

["This test helps diagnose or monitor conditions related to abnormal protein patterns in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55902-1
Short code
IgA Ser Elph-mCnc
Synonyms
IgA Ser Elph-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Electrophoresis separates proteins in your serum based on size and electrical charge. The test specifically quantifies IgA levels among other proteins, providing a detailed profile of your protein composition. This can help identify imbalances that may signal conditions like immune disorders, liver disease, or kidney problems.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like frequent infections, unexplained weight loss, swelling, or if they suspect conditions such as immune deficiencies, protein disorders, or certain types of cancer. It may also be used as part of a broader evaluation for chronic diseases.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum (the liquid part without clots) before being sent to the lab for electrophoresis. This process typically takes a few minutes, and you may experience a brief pinch or discomfort during the draw.

Test Results and Interpretation

Results show the concentration of IgA and other proteins in your serum. While specific reference ranges vary by lab, abnormal patterns (e.g., elevated or reduced IgA levels) may indicate underlying health issues. Your doctor will discuss results with you in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgA Protein Profile

Frequently asked questions

What could abnormal results mean?
Low IgA levels may suggest immune system dysfunction, such as selective IgA deficiency, which can increase susceptibility to infections. High IgA levels could be associated with autoimmune diseases, certain cancers (like multiple myeloma), or chronic inflammatory conditions. Abnormal protein patterns detected during electrophoresis can also help diagnose conditions like nephrotic syndrome or liver disease.
How is this test different from other IgA tests?
This test uses electrophoresis to provide a comprehensive protein profile, including IgA levels among other proteins like albumin and globulins. Other IgA tests (like immunoassays) typically measure IgA concentration alone without detailed protein separation.
What preparation is needed before this test?
No special preparation is usually required, but you may be asked to avoid certain medications (like steroids) that could affect protein levels. If you have a history of bleeding disorders or take blood thinners, inform your doctor beforehand.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy