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Insulin-like Growth Factor Binding Protein 3 (IGFBP3) – Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of insulin-like growth factor binding protein 3 (IGFBP3) in your blood. It helps assess hormone balance, growth processes, and potential metabolic or endocrine conditions.

Quick summary

["IGFBP3 supports hormone regulation and may indicate growth or metabolic health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33654-5
Short code
IGF BP3 1h p chal SerPl-mCnc
Synonyms
IGF BP3 1h p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions linked to growth hormone dysfunction, such as abnormal growth in children, metabolic disorders, or hormonal imbalances. It may also be used in research or specialized clinical evaluations.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your test involves blood collection. Wear a loose shirt for easy access to your arm.

How the Test Works

A small sample of blood is drawn from a vein in your arm. The sample is sent to a lab where it is analyzed using an immunoassay method to measure IGFBP3 levels.

What the Results Mean

Results are compared to a reference range specific to the lab, though exact values may vary. Elevated or low levels could signal conditions like growth hormone excess, metabolic syndrome, or other endocrine disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

IGFBP3 plays a role in transporting insulin-like growth factors, which influence cell growth and metabolism. Abnormal levels may indicate underlying endocrine disorders, such as acromegaly (excess growth hormone) or growth hormone deficiency, or be part of broader metabolic assessments.

Short name

IGFBP3 Level

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Follow-up with your healthcare provider to discuss findings.
What does a low IGFBP3 level mean?
Low levels may suggest conditions affecting growth hormone regulation, such as pituitary disorders or metabolic issues. Your provider will interpret results in context with your symptoms and medical history.
Can diet or exercise affect IGFBP3 levels?
Dietary factors (e.g., protein intake) and exercise may indirectly influence IGFBP3, but results are based on your blood sample at the time of testing. Avoid extreme dietary changes before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy