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Insulin-like Growth Factor Binding Protein 3 (IGFBP-3) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the concentration of IGFBP-3, a protein that helps regulate how insulin-like growth factors interact with cells in your body. It may be checked to assess growth hormone function or metabolic health.

Quick summary

["IGFBP-3 helps balance growth factors and may reflect metabolic or hormonal health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33658-6
Short code
IGF BP3 2h p chal SerPl-mCnc
Synonyms
IGF BP3 2h p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may request this test if they suspect conditions like growth hormone deficiency, acromegaly, or metabolic disorders. It could also be part of a broader evaluation for bone health, muscle function, or diabetes management.

What to Expect Before the Test

No special preparation is usually needed. You may have a simple blood draw, and you can eat and drink normally unless instructed otherwise. If you’re taking certain medications, let your provider know.

What the Results Mean

Results are interpreted based on your overall health, symptoms, and medical history. Abnormal levels may signal issues with growth hormone regulation or metabolic function, but this requires professional evaluation.

Common Conditions Linked to IGFBP-3 Levels

High or low IGFBP-3 levels may be associated with growth hormone imbalances, diabetes, or metabolic syndrome. Your provider will discuss findings in the context of your diagnosis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IGFBP-3 Level

Frequently asked questions

What does a high IGFBP-3 level usually indicate?
A high level may suggest conditions like acromegaly (overactive growth hormone) or certain metabolic disorders, but it can also occur without a specific diagnosis. Your provider will review your full medical picture.
Can diet or exercise affect IGFBP-3 levels?
Diet and exercise can influence IGFBP-3 indirectly, especially if they impact growth hormone or metabolic health. However, results are based on your blood sample at the time of testing, so lifestyle factors alone won’t change the immediate test outcome.
Is IGFBP-3 testing painful?
Most people experience mild discomfort during a blood draw, similar to a needle prick. The area may feel tender afterward, but it’s a quick procedure. If you have a fear of needles, let your provider know for alternative options.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy