Skip to content

Insulin-like Growth Factor Binding Protein 3 (IGFBP3) Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of IGFBP3, a protein that helps regulate how insulin-like growth factors affect cells, particularly in growth and metabolism.

Quick summary

["IGFBP3 levels can provide insight into growth hormone function and metabolic health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33808-7
Short code
IGF BP3 SerPl-sCnc
Synonyms
IGF BP3 SerPl-sCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if they suspect conditions linked to abnormal growth hormone signaling, such as growth disorders in children, metabolic syndrome, or certain cancers. It could also be part of a broader evaluation for hormonal imbalances or to monitor treatment responses.

What to Expect Before the Test

No special preparation is typically needed. You may fast for 8–12 hours before the test if instructed, but always follow your provider’s specific instructions. Bring any medications you’re currently taking, as some may affect results.

How the Test Is Performed

A blood sample is drawn from a vein in your arm by a healthcare professional. The blood is sent to a lab where it is processed to separate serum for analysis. The test measures IGFBP3 concentration using immunoassay.

What the Results Mean

Results are compared to a reference range specific to your age, sex, and health status. Elevated levels may indicate overactive growth hormone signaling, while low levels could suggest growth hormone deficiency or other metabolic issues. Your provider will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IGFBP3 Level

Frequently asked questions

How might IGFBP3 levels be affected by certain conditions or medications?
IGFBP3 levels can be influenced by growth hormone imbalances, metabolic disorders (e.g., diabetes), kidney disease, or certain cancers. Some medications, like steroids or anticonvulsants, may also alter results. Always discuss your medical history and current medications with your provider before interpreting results.
What if my results are outside the normal range?
If your results are outside the expected range, your provider will work with you to determine the cause. This may involve additional tests, lifestyle changes, or adjustments to medications. Follow-up may include retesting or further evaluation to address any underlying conditions.
Can I eat or drink anything before this test?
Check with your healthcare provider for specific instructions, but generally, fasting for 8–12 hours before the test is recommended unless you have a condition that requires dietary restrictions. Avoid caffeine or alcohol before testing, as they may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy