Skip to content

Insulin-like Growth Factor Binding Protein 3 (IGFBP3) Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of insulin-like growth factor binding protein 3 (IGFBP3) in your blood. IGFBP3 helps regulate how IGFs affect cells, particularly in growth and metabolism.

Quick summary

["IGFBP3 levels can offer insights into growth hormone function and potential metabolic health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
60004-9
Short code
IGF BP3 sp1 p chal SerPl-mCnc
Synonyms
IGF BP3 sp1 p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may request this test if they suspect conditions like growth hormone disorders, metabolic syndrome, or liver disease. It could also be part of monitoring for conditions affecting IGF signaling or growth-related symptoms.

What to Expect During the Test

A blood sample will be drawn from a vein, usually in your arm. You may feel a slight pinch, but it’s typically quick and painless. No special preparation is needed unless directed by your provider.

Common Conditions Monitored

IGFBP3 levels are sometimes checked in patients with suspected growth hormone imbalances, liver disease, or metabolic disorders. It may also be used in research or specialized clinical settings to assess IGF signaling pathways.

How Results Are Interpreted

Results are compared to a reference range for your age, sex, and health status. While specific ranges vary, abnormal levels may indicate underlying issues that require further evaluation, such as hormone imbalances or organ dysfunction.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: IGFBP3’s Role in Health

Short name

IGFBP3 Level

Frequently asked questions

IGFBP3 plays a role in transporting and regulating IGFs, which influence growth, cell repair, and metabolism. Low levels may suggest growth hormone deficiency or liver issues, while high levels could be linked to certain metabolic or endocrine conditions. Always discuss results with your provider for personalized interpretation.
This test is primarily used to assess IGF signaling or monitor conditions affecting IGFBP3 levels, such as liver disease or growth hormone disorders. It’s not a routine screening test for most conditions.
Will I need to prepare for this test?
No special preparation is usually required. However, avoid heavy meals or excessive alcohol before the draw if instructed by your provider, as it may affect blood test results.
How long will I wait for my results?
Results may take several days to a week, depending on your lab’s processing schedule. Your healthcare provider will contact you once they’re ready to discuss your results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy