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Immunoassay for Immunoglobulin G (IgG) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin G (IgG), a type of antibody in your blood. IgG helps protect your body from infections and is the most common antibody in the blood.

Quick summary

["IgG helps fight infections and supports long-term immunity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
12909-8
Short code
IGF-I 30M p chal SerPl-mCnc
Synonyms
IGF-I 30M p chal SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does IgG Measure?

IgG is the primary antibody your immune system produces in response to infections, vaccines, and chronic illnesses. It circulates in your bloodstream and provides long-lasting protection against pathogens like bacteria and viruses. Levels of IgG can vary depending on your health status, immune response, and exposure to infections or vaccines.

Why Is IgG Tested?

Doctors may order an IgG test to diagnose or monitor conditions such as immune deficiencies, autoimmune diseases, infections, or to assess immune responses after vaccination. It can also help evaluate how well your immune system is functioning in people with chronic illnesses like HIV or cancer.

When Might You Need This Test?

You might need an IgG test if you have symptoms of a weakened immune system, such as frequent infections, slow wound healing, or unexplained fatigue. It may also be part of a routine check-up for people with certain genetic or chronic conditions that affect immunity.

What to Expect Before the Test

No special preparation is usually needed for this blood test. You may be asked to fast for 8–12 hours before the test if it’s part of a broader metabolic or immune panel. On the day of the test, wear comfortable clothing and avoid eating or drinking anything (except water) if fasting is required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

IgG levels can indicate immune system health, help diagnose conditions like immunodeficiency, or assess immune responses to infections or vaccines. Low IgG levels may suggest an underlying immune disorder, while very high levels could be linked to chronic infections, autoimmune diseases, or certain medications.

Short name

IgG Level

Frequently asked questions

What causes IgG levels to be low?
Low IgG levels can result from primary immune deficiencies (like Common Variable Immunodeficiency), chronic illnesses (such as HIV or liver disease), malnutrition, or certain medications. It may also appear in people with autoimmune diseases or those who have had organ transplants.
What causes IgG levels to be high?
High IgG levels can be due to chronic infections (like hepatitis or tuberculosis), autoimmune diseases (such as rheumatoid arthritis or lupus), certain cancers (like multiple myeloma), or long-term exposure to vaccines or blood products.
Does diet affect IgG levels?
Diet can indirectly influence IgG levels by affecting overall health. A balanced diet rich in vitamins, minerals, and protein supports immune function, but IgG levels are primarily determined by immune system activity and response to infections or vaccines.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy